The Store-operated Calcium Entry Pathways in Human Carcinoma A431 Cells
نویسندگان
چکیده
منابع مشابه
The Store-operated Calcium Entry Pathways in Human Carcinoma A431 Cells
Activation of phospholipase C (PLC)-mediated signaling pathways in nonexcitable cells causes the release of Ca2+ from intracellular Ca2+ stores and activation of Ca2+ influx across the plasma membrane. Two types of Ca2+ channels, highly Ca2+-selective ICRAC and moderately Ca2+-selective ISOC, support store-operated Ca2+ entry process. In previous patch-clamp experiments with a human carcinoma A...
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roles in regulating cell functions such as chemotaxis, motility or secretion. Stimulation by neurotransmitters or hormones activates intracellular production of inositol 1, 4, 5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 binds to the IP3 receptor on the Ca store (endoplasmic reticulum ; ER) membrane and releases the sequestered Ca to the intracellular space. Increased intracellular Ca fu...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2003
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.200308815